Revealing the pathway to life

Determining the functional activity of tumor-driving signal transduction pathways

Building on decades of cell biology research, unravelling the mechanisms driving tumor growth.

Essential knowledge has been acquired on the role of signal transduction pathways in cancer growth, providing input for development of drugs targeting signaling pathways. Identification of the tumor-driving pathway and its causative defect is crucial for selecting the most effective therapy.

10-15 Signal transduction pathways are known to drive cancer growth; Targeted drugs target the following pathways: Estrogen receptor (ER) and Androgen receptor (AR), Wnt, Notch, Hedgehog, TGF-ß, NF-κB and the growth factor stimulated signaling pathways: phosphoinositide 3-kinase/AKT/FOXO, RAS/MAPK/ERK and JAK/STAT.

Testing "down-stream" for mRNA transcription of the target genes of pathways OncoSignal enables functional assessment of pathway activity in tumor samples. The expression levels of selected target genes of these pathways are measured using our qPCR test kit; our sophisticated computational models interpret the data and indicate the activity scores of the different pathways. OncoSignal is applicable across a broad range of cancer types.

OncoSignal brochure

An overview of OncoSignal pathway studies performed on different tissue types and various cancers.

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The team behind OncoSignal

Paul van de Wiel
General Manager MPDx

25 Years of international experience in management of molecular diagnostics business in leading companies (Organon Teknika, bioMerieux, Philips). Proven track record in development, regulatory approvals (FDA 510k/PMA and CE-IVD) and marketing of molecular diagnostic tests.

Sigi Neerken
Clinical Account Management and Business Development MPDx

15 Years of experience in research, new business development and strategic program management at Philips Research.

Eveline den Biezen
Product Development and Services MPDx

20 Years of experience in product development, operations and service lab management of molecular diagnostics at Organon Teknika, Primagen, bioMerieux and Philips.

Jos Rijntjes
Marketing and Sales MPDx

30 Years of experience in global marketing & sales, product & business development and program management of in-vitro diagnostics (immunoassays and molecular diagnostics) at Organon Teknika, Primagen and Philips. Member of the management team of a startup (Primagen) and a corporate venture within Philips (Handheld Diagnostics).

MPDx (Molecular Pathway Diagnostics) is a venture within Philips HealthWorks.

Publications and links

• Philips IntelliSpace Genomics

• Knowledge-based computational models; OncoTarget, 2014, Vol. 5, No. 14

• Selection of Personalized Patient Therapy through the Use of Knowledge-Based Computational Models That Identify Tumor-Driving Signal Transduction Pathways; Cancer Res, 2014;74:2936-2945

• Predicting first line tamoxifen response of recurrent ER+ breast cancer patients based on transcriptional activity of signaling pathways; Poster, AACR 2016

• Prognosis within different breast cancer subtypes using functional activity of signaling pathway; Poster, AACR 2015

• ER-pathway activity as a predictive biomarker for neo-adjuvant endocrine therapy: Results of the TEAM IIA trial; Poster, SABCS 2015

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